BIOLOGY 353 - Spring 2004
This course is designed to provide you with an integrated
view of genetic principles and to introduce you to the fundamental concepts in
transmission, molecular and population genetics. Dr. Khaleel will teach from
January 14-April 7 and Dr. Butler will teach the topics on population genetics
from April 12-23. To understand transmission genetics, you must learn to apply
the principles learnt in class and make inferences from case studies discussed.
To accomplish this, you will be assigned case study problems that involve
analysis of data. As time permits,
these problems will also be discussed in class. Genetics has become an indispensable component of almost all
research in biology and medicine and the continual flood of discoveries impacts
our daily lives. Reading
pertinent articles is therefore, an important component of this course.
These articles will be assigned to you periodically and discussed in
class (as time permits). Hopefully,
this will expose you to the process of science and help you expand your
understanding about heredity. You are encouraged to read other Genetics texts
placed in the Science Conference Room on some of the topics that are not covered
to the desirable detail in the required text. A CD-ROM (packaged with the text),
solution Manual (sold separately), Science on the Internet (companion website)
are available as additional learning tools.
REQUIRED
TEXT: Concepts
of Genetics by Klug
and Cummings. (7th
Edition, 2003).
Office & Office Hours:
Dr. Khaleel: Office:
SCI 119 Phone:
657-2017 Office Hours: TTH
12.30 -2.30 and by appointment
Dr. Butler: Office: SCI 137 Phone: 657-2015 Office Hours: Tp be announced
EXAMINATIONS AND ASSESSMENT: Outcomes Assessment of the learning objectives described above will be done through examinations, assigned genetics problems, and participation in discussions of research articles during the class. Examinations will consist of essay and short answer questions and genetics problems. Four examinations will be given on the dates indicated below. Please note that all examinations are scheduled during the lab time and Exam 4 during the final examinations week.
Exam 1
February 12
Exam 2 March 18
Exam 3 April 1
Exam 4 April 29 (Thursday: 12-1:50)
GRADING
SCALE: 91-100% =A; 81-90% = B; 71-80%
= C; 61-70% = D
Topics
to be covered and Reading Assignments
Topic
Chapter
Introduction:
Historical Perspectives 1
The Branches of Genetics
Relationship of Genetics to other areas of Biology
Geneticists and Genetic Research
The Development of the Field of Genetics
Chromosomal
Basis of Inheritance
2, 11
a. Structure and function of chromosomes
b. Mitosis and Meiosis
c. The Chromosome theory of Inheritance
Genotype
and Phenotype
9,10,12,13
DNA, RNA and genetic expression
(specific sections will be identified)
Mendelian Concepts and Analysis 3
a. Mendel's Experiments and Analytical Approach
c. Modern Genetic Terminology
d. Monohybrid, Dihybrid and Trihybrid crosses
e. The Test Cross
f. Probability, Chi-square and Pedigree Analysis
Extensions
to Mendelian Analysis
4
a. Modifications of Dominance
b. Multiple Alleles
c. Essential genes and Lethal Alleles
d. Gene Interactions and Modified Mendelian Ratios
Quantitative Genetics 5
a. Polygenic (Quantitative) traits and their inheritance
b. Penetrance and Expressivity
c. Environment, Gene Expression and Heritability
Linkage
and Chromosome Mapping
6
a. The Discovery of Linkage
b. Gene Recombination
c. Construction of Genetic maps
d. Detecting Linkage Through Testcrosses
e. Two point and Three-point Testcross
Sex Determination and sex chromosomes 7
Mutations 8
a. Mutations: a General Survey
b. Variations in Chromosome Structure
c. Variations in Chromosome Number
Population
Genetics and Evolution
25, 26,27